CIPRODEX
Combination product
Pronunciation: sip-roe-FLOX-a-sin and dex-a-METH-a-soen
Combination of Ciprofloxacin and Dexamethasone.
Each component keeps its own pharmacology page; the combination itself adds no new mechanism.
Components (2)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Acute otitis media with tympanostomy tubes (S. aureus, S. pneumoniae, H. influenzae, M. catarrhalis, P. aeruginosa) | Pediatric >=6 months | 4 drops into affected ear BID | 4 drops BID | 7 days |
| Acute otitis externa (S. aureus, P. aeruginosa) | >=6 months, adults, and elderly | 4 drops into affected ear BID | 4 drops BID | 7 days |
Renal Undefined
Hepatic Undefined
Instructions
- For otic (ear) use only — not for ophthalmic use; not for injection
- Shake well immediately before use; warm bottle in hand 1–2 minutes to avoid dizziness
- Lie with affected ear upward; for AOM, pump the tragus 5 times; maintain position 60 seconds
- Discard unused portion after therapy is completed
Available strengths
- susp 0.3/0.1 %
Contraindications
- Viral infections of the external canal, including herpes simplex
Cautions
- Overgrowth of nonsusceptible organisms (yeast/fungi) with prolonged use
- Discontinue at first sign of skin rash/hypersensitivity
- Serious/fatal systemic hypersensitivity (anaphylactic) reactions reported with systemic quinolones
Adverse reactions
- Ear discomfort
- Ear pain
- Ear pruritus
- Ear debris/residue (precipitate)
Pregnancy Pregnancy Category C; animal studies with ciprofloxacin showed no teratogenicity; corticosteroids are teratogenic in animals; systemic exposure is low with otic use.
Lactation Undefined
Cost
CIPRODEX
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 0.3/0.1 % | susp | per unit | not offered |
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. CIPRODEX is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.
Part D rank #515.