Cilastatin
in PRIMAXIN
Pronunciation: sye-la-STAT-in
What it isRenal dehydropeptidase inhibitor; never given alone, always with imipenem (PRIMAXIN, and with relebactam in RECARBRIO).
Why this oneIt limits the renal metabolism of imipenem, which is why imipenem is not given without it.
What limits itNot an antibacterial itself: spectrum, seizure risk and renal dose adjustment all belong to imipenem.
NO BOXED WARNINGS