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Calcium carbonate

TUMS

Pronunciation: KAL-see-um KAR-bon-ayt

Calcium carbonate ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Calcium carbonate ballicule

What it isCalcium salt acting as an antacid and supplement.

Why this oneCheapest calcium source and best absorbed with food, and it doubles as an antacid and phosphate binder.

What limits itIt needs gastric acid, so citrate is preferred on a PPI. Constipation; it binds levothyroxine and quinolones.

Calcium carbonate molecular structure (skeletal formula)
Molecular structure: Calcium carbonate

FDA-approved for

FDA label

FDA dosingPopulationStartTargetMax
Acid indigestion / heartburn (OTC antacid)Adults & children ≥12 yChew 2–4 tablets PRN as symptoms occurChew 2–4 tablets PRN as symptoms occurNot stated on label

Renal Undefined

Hepatic Undefined

Instructions

Available strengths

Pregnancy Undefined

Lactation Undefined

Cost

Calcium carbonate (TUMS)
What pharmacies pay · NADAC 9/30/26 · OTC
Strength#/mogeneric $/unitCostPlus
400 mgchew tabper unitnot offered
420 mgchew tabper unitnot offered
500 mgchew tabper unit$0.02/eanot offered
750 mgchew tabper unit$0.03/eanot offered
1000 mgchew tabper unit$0.04/eanot offered
1177 mgchew tabper unitnot offered
1500 mgchew tabper unitnot offered

NO BOXED WARNINGS

Principal riskConstipation; binds other drugs in the gut

Classes and tags

Clinical profile

Therapeutic safety burden1 / 4
Weight-gain liability0 / 4
Sedation liability0 / 4
Direct muscarinic antagonism0 / 4
Embryofetal risk1 / 4

Defining liabilityConstipation and excessive-use hypercalcemia or milk-alkali syndrome

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