Butabarbital

BUTISOL

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Pronunciation: byoo-ta-BAR-bi-tal

Butabarbital ballicule: receptor binding, kinetics and half-life diagram — Mechanism of action: Butabarbital ballicule

Butabarbital BUTISOL mascot mnemonic cartoon — Visual mnemonic: Butabarbital mascot
**“Butter barb”**

What it isAn intermediate-acting barbiturate sedative-hypnotic acting as a GABA-A positive allosteric modulator.

Why this oneIt survives as one of the last oral barbiturate hypnotics on the US market, where nearly all of that class has been retired.

What limits itTolerance develops within weeks, withdrawal can be life-threatening, and CYP induction plus a narrow therapeutic index make it a poor choice against modern hypnotics.

Butabarbital molecular structure (skeletal formula) — Molecular structure: Butabarbital

FDA-approved for

sedative-hypnotic

NO BOXED WARNINGS

Classes and tags

Schedule III controlled substances

Clinical profile

Therapeutic safety burden3 / 4

Sedation liability3 / 4

Direct muscarinic antagonism0 / 4

Embryofetal risk3 / 4

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