Brexanolone
ZULRESSO
Pronunciation: brex-AN-oe-loen (zul-RE-soe)
“Zulu resigns (to) Brex (feed) alone”
What it isIntravenous allopregnanolone; postpartum depression.
Why this oneResponse within 60 hours, where oral antidepressants take weeks — it replaces the neurosteroid that falls after delivery.
What limits itA 60-hour inpatient infusion with continuous monitoring for excessive sedation and loss of consciousness, under a REMS.
FDA-approved for
- postpartum depression (2019)
⚠ BOXED WARNING
- Excessive sedation and sudden loss of consciousness
Classes and tags
Clinical profile
Legacy pregnancy categoryN/A (post-2015 labeling)
Defining liabilitySudden loss of consciousness during prolonged monitored infusion
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