Benazeprilat
from benazepril
What it isThe active metabolite of benazepril — the diacid that actually inhibits ACE.
Why it mattersBenazepril is an ester prodrug; essentially all of its effect is this molecule, generated by hepatic esterases.
What it changesIts renal clearance, not the parent’s, is what accumulates in kidney disease and drives dose adjustment.
NO BOXED WARNINGS