Baclofen

LIORESAL

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Pronunciation: BAK-loe-fen

Baclofen ballicule: receptor binding, kinetics and half-life diagram — Mechanism of action: Baclofen ballicule

Baclofen LIORESAL mascot mnemonic cartoon — Visual mnemonic: Baclofen mascot
**“Liar’s resale Back fin”**
intrathecal baclofen pump
hat resembles GABA-B agonist peg

What it isGABA-B receptor agonist; spasticity of spinal origin.

Why this oneIntrathecal delivery makes it uniquely useful for severe spinal spasticity when oral sedation prevents adequate treatment.

What limits itRenal accumulation can cause encephalopathy; abrupt withdrawal can cause rebound spasticity, delirium or seizures — especially from a pump.

Baclofen molecular structure (skeletal formula) — Molecular structure: Baclofen

FDA-approved for

spasticity (1977)

Off-label

alcohol use disorder
hiccups

FDA label

Read the full label on DailyMed ↗

FDA dosing	Population	Start	Target	Max
Spasticity (e.g., multiple sclerosis, spinal cord conditions)	Adult	5 mg TID	40-80 mg/day divided (titrate)	80 mg/day (20 mg QID)

Titration Increase dose every 3 days per titration schedule

Renal Undefined

Hepatic Undefined

Instructions

Titrate to lowest dose compatible with optimal response
Do not stop abruptly — withdraw slowly to avoid withdrawal (hallucinations, seizures, rebound spasticity)

Available strengths

tab 5, 10, 15, 20 mg
inj 0.05, 0.5, 1, 2 mg/mL
granules 5, 10, 20 mg/packet
sol 5, 10 mg/5 mL
susp 25 mg/5 mL

Cautions

Abrupt withdrawal can cause hallucinations and seizures — taper
Caution where spasticity maintains upright posture/balance or function
Transient drowsiness — may impair ability to operate machinery/drive

Adverse reactions

Transient drowsiness (10-63%)
Dizziness (5-15%), weakness (5-15%)
Fatigue
Nausea (4-12%), constipation
Hypotension, headache, insomnia

Pregnancy Undefined

Lactation Undefined

Cost

Baclofen (LIORESAL)

What pharmacies pay · NADAC 9/30/26

Strength		#/mo	generic $	CostPlus
5 mg	tab	90 TID	$6.12/mo	offered
10 mg	tab	90 TID	$2.88/mo	offered
15 mg	tab	90 TID	$150/mo	not offered
20 mg	tab	90 TID	$4.67/mo	offered
0.05 mg/mL	inj	per unit		not offered
0.5 mg/mL	inj	per unit		not offered
1 mg/mL	inj	per unit		not offered
2 mg/mL	inj	per unit		not offered

Generic entry1988

NO BOXED WARNINGS

Principal riskAbrupt withdrawal can cause seizures and rebound spasticity

Classes and tags

Clinical profile

Therapeutic safety burden2 / 4

Overdose danger3 / 4

Weight-gain liability0 / 4

Sedation liability2 / 4

QT / Torsades0 / 4

Direct muscarinic antagonism0 / 4

Embryofetal risk2 / 4

Legacy pregnancy categoryUnknown / historical label unavailable

Defining liabilityGenerally tolerated at therapeutic doses; clinically important risks are agent-specific and increase with interactions or organ impairment.

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Memory aids: interaction avatars

no kinetic interactions

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