Avibactam
in AVYCAZ
Pronunciation: a-vi-BAK-tam
What it isA non-beta-lactam (diazabicyclooctane) beta-lactamase inhibitor paired with ceftazidime.
Why this oneIt inactivates KPC and other class A/C (and some class D) carbapenemases that clavulanate-era inhibitors cannot touch, restoring ceftazidime against carbapenem-resistant Enterobacterales.
What limits itIt has no useful antibacterial activity alone and does not cover metallo-beta-lactamases.
NO BOXED WARNINGS
Classes and tags
Clinical profile
Defining liabilityRenal accumulation; used only with companion antibiotics