Androstanediol
3α-androstanediol
What it isEndogenous neurosteroid derived from dihydrotestosterone, a GABA-A positive modulator.
Why this oneIt links androgen levels to GABAergic tone, which is one route by which testosterone affects mood and anxiety.
What limits itIt is why 5-alpha reductase inhibitors can affect mood — they block its synthesis as well as DHT.
NO BOXED WARNINGS
Principal riskEndogenous or dietary; no boxed warning applies