Amyl nitrite
popper
What it isInhaled nitric oxide donor; historical use in angina and cyanide poisoning.
Why this oneIt acts within seconds by inhalation, which no oral nitrate matches.
What limits itMethemoglobinemia was the point in cyanide poisoning but is a hazard otherwise. Recreational use with PDE5 inhibitors causes fatal hypotension.
FDA-approved for
- cyanide poisoning (historical)
- angina (historical)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Not stated on label | Adults and children | 5 pellets SL TID at symptom onset | 5 pellets SL TID | Undefined |
Renal Undefined
Hepatic Undefined
Instructions
- Dissolve 5 pellets under the tongue.
- Begin at the onset of symptoms.
- Continue until symptoms are relieved or as directed by a doctor.
Available strengths
- inhaler 0.3 g/.3 mL
Pregnancy Undefined
Lactation Undefined
Cost
Amyl nitrite (POPPER)
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 0.3 g/.3 mL | inhaler | per unit | not offered |
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. Amyl nitrite is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.
NO BOXED WARNINGS
Principal riskMethemoglobinemia was the point in cyanide poisoning but is a hazard otherwise