D-Alanine
NMDA co-agonist
What it isD-alanine, a co-agonist at the NMDA receptor glycine site.
Why this oneThe glycine site requires a co-agonist for the channel to open at all, which is why it is a drug target.
What limits itIt is a reminder that NMDA blockade can be achieved at the glycine site as well as in the channel.
NO BOXED WARNINGS
Principal riskEndogenous or dietary; no boxed warning applies