Agmatine
endogenous
What it isDecarboxylated arginine acting at imidazoline receptors and as a negative modulator at the NMDA polyamine site.
Why this oneIt is a putative neuromodulator that sits at the junction of the nitric oxide and glutamate systems.
What limits itHuman evidence for the supplement is limited, and oral bioavailability is poor.
FDA-approved for
- dietary supplement (no approved indication)
Off-label
- neuropathic pain (limited human evidence)
NO BOXED WARNINGS
Principal riskEndogenous or dietary; no boxed warning applies