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Activated charcoal

charcoal

Activated charcoal ballicule: receptor binding, kinetics and half-life diagram
Mechanism of action: Activated charcoal ballicule

What it isNonabsorbed toxin sequestrant that adsorbs many drugs in the gut; selected acute oral poisonings.

Why this oneIt can broadly reduce absorption when given promptly, unlike antidotes that target only one toxin.

What limits it⚑ It does not bind iron, lithium, alcohols, or hydrocarbons; aspiration can be lethal, so withhold if the airway is unprotected.

FDA label

FDA dosingPopulationStartTargetMax
Emergency adsorption of swallowed poisonsAll (as directed by a health professional)20–30 g PO in ≥8 oz liquid ×120–30 g; repeat dose immediately if possibleUndefined

Renal Undefined

Hepatic Undefined

Instructions

Available strengths

Contraindications

Cautions

Pregnancy Undefined

Lactation Undefined

Cost

Activated charcoal (CHARCOAL)
Strength#/mogeneric $/unitCostPlus
25 g/240 mLsuspper unitnot offered
208 mg/mLsuspper unitnot offered
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. Activated charcoal is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.

NO BOXED WARNINGS

Principal riskUseless for iron, lithium, alcohols and hydrocarbons

Classes and tags

Clinical profile

Therapeutic safety burden2 / 4
Sedation liability0 / 4
QT / Torsades0 / 4
Direct muscarinic antagonism0 / 4

Defining liabilityAspiration injury; gastrointestinal obstruction

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