Not available in the U.S.
Aceclidine
VIZZ
Pronunciation: a-SEK-li-deen (VIZ)
What it isMuscarinic agonist eye drop; glaucoma and presbyopia.
Why this oneIt constricts the pupil with less ciliary spasm than pilocarpine, so near vision improves without the brow ache.
What limits itNot US-approved for glaucoma. Dim vision in low light; avoid in retinal disease.
FDA-approved for
- presbyopia (2025)
- glaucoma (non-US)
Off-label
- glaucoma (approved in Europe)
FDA label
Read the full label on DailyMed ↗
| FDA dosing | Population | Start | Target | Max |
|---|---|---|---|---|
| Presbyopia | Adult | 1 drop each eye, wait 2 min, then a 2nd drop each eye, QD | 1 drop each eye ×2 (2 min apart) QD | QD |
Renal Undefined
Hepatic Undefined
Instructions
- Remove contact lenses before instillation; may reinsert 10 minutes after.
- If using another topical ophthalmic, separate by at least 5 minutes.
- Use the same single-dose vial for both drops; discard after use.
- Avoid touching the vial tip to the eye or any surface.
Available strengths
- drops 1.44 %
Cautions
- Blurred/dim vision — do not drive or operate machinery until vision is clear; caution with night driving.
- Rare retinal tear/detachment with miotics — examine retina before therapy; seek care for sudden flashes, floaters, or vision loss.
- Caution in patients with a history of iritis (may exacerbate synechiae).
- Not recommended with known hypersensitivity to aceclidine.
Adverse reactions
- Instillation-site irritation (20%)
- Dim vision (16%)
- Headache (13%)
- Conjunctival hyperemia (8%)
- Ocular hyperemia (7%)
Pregnancy No adequate human data; oral animal studies showed no adverse maternal/fetal effects at clinically relevant doses.
Lactation No data on presence in human milk; systemic levels low after topical ocular use.
Cost
Aceclidine (VIZZ)
| Strength | #/mo | generic $/unit | CostPlus | |
|---|---|---|---|---|
| 1.44 % | drops | per unit | not offered |
NADAC is a voluntary CMS survey of what retail community pharmacies pay for the drugs they stock. Aceclidine is dispensed outside retail pharmacies, so it rarely appears on surveyed invoices.
NO BOXED WARNINGS
Principal riskNot US-approved for glaucoma