7-OH loxapine
What it isThe 7-hydroxy metabolite of loxapine, more D2-potent than the parent.
Why it mattersIt contributes substantially to loxapine’s antipsychotic effect at doses that seem modest.
What it changesIt is one of two routes from loxapine; the other, N-demethylation, yields amoxapine and its antidepressant activity.
FDA-approved for
- schizophrenia (metabolite of loxapine)
NO BOXED WARNINGS
Principal riskLittle in its own right; see the parent drug